張海偉，藥理學(xué)博士，副研究員，碩士生導(dǎo)師。中國(guó)抗癌協(xié)會(huì)腫瘤標(biāo)志委員會(huì)遺傳腫瘤標(biāo)志協(xié)作組秘書，主要從事腫瘤個(gè)體化用藥分子檢測(cè)和臨床咨詢工作，研究方向?yàn)槟[瘤分子藥理，目前主持省部級(jí)課題5項(xiàng)，已結(jié)題3項(xiàng)，發(fā)表文章總影響因子為62.8，總引用次數(shù)466次，Oncogene，Euro Pharma J等雜志同行評(píng)議人。

教育經(jīng)歷：

2005/09 - 2010/06, 中國(guó)藥科大學(xué)，藥學(xué)院，博士；導(dǎo)師：郭青龍

2007/05 – 2010/03，清華大學(xué)，醫(yī)學(xué)院，博士生；導(dǎo)師：常智杰

2001/09 – 2005/06，中國(guó)藥科大學(xué)，藥學(xué)院，本科

科研與學(xué)術(shù)工作經(jīng)歷：

2017/3-2018/3, 德克薩斯大學(xué)休斯頓健康醫(yī)學(xué)中心, 整合生物化學(xué)和藥學(xué)院, 訪問學(xué)者

2012/07 - 至今，重慶市腫瘤研究所，腫瘤實(shí)驗(yàn)室，副研究員

2011/09-2012/06，東南大學(xué)醫(yī)學(xué)院，博士后，合作導(dǎo)師：陳寶安

2010/07 - 2012/06，中國(guó)藥科大學(xué)，藥學(xué)院生理教研室，講師

2007/05 – 2010/03，清華大學(xué)，醫(yī)學(xué)院，博士生

主持或參加科研項(xiàng)目（課題）及人才計(jì)劃項(xiàng)目情況（按時(shí)間倒序排序）：

1. 重慶市自然基金，cstc2017jxjl0164, lncRNA CTB在漢黃芩素逆轉(zhuǎn)阿霉素耐藥中的作用機(jī)制研究，2017/12-2019/12, 10萬(wàn)元，主持

2. 重慶市自然基金，cstc2016jcyjA0107，lncRNA CTB在監(jiān)測(cè)乳腺癌新輔助化療TA方案療效中作用及機(jī)制研究，2016/03-2018/06,5萬(wàn)元，主持

3. 重慶市自然基金，cstc2013jcyjA1513，漢黃芩素通過調(diào)節(jié)CDKs影響人腫瘤細(xì)胞周期機(jī)制研究 2013/03-2016/03，8萬(wàn)元，在研，主持

4. 江蘇省自然基金，BK2011620，基于調(diào)控細(xì)胞內(nèi)氧化還原系統(tǒng)的FV-429誘導(dǎo)腫瘤細(xì)胞死亡的機(jī)制研究，2011.12-2014.12，5萬(wàn)元，已結(jié)題，主持

5. 國(guó)家自然科學(xué)基金，81202611，控WNT信號(hào)通路逆轉(zhuǎn)腦膠質(zhì)瘤干細(xì)胞耐藥的作用機(jī)制研究，2013/01-2015/12，20萬(wàn)元，已結(jié)題，參加

代表性研究成果和學(xué)術(shù)獎(jiǎng)勵(lì)情況

一、期刊論文

1. 第一作者論文

(1) H. Zhang, Y. Zhang, S.S. Ng, F. Ren, Y. Wang, Y. Duan, L. Chen, Y. Zhai, Q. Guo*, Z. Chang*, Dishevelled-DEP domain interacting protein (DDIP) inhibits Wnt signaling by promoting TCF4 degradation and disrupting the TCF4/beta-catenin complex, Cell Signal, 2010, 22:1753-1760.

(2) Zhang H, Chen F, He Y et al. Sensitivity of non-small cell lung cancer to erlotinib is regulated by the Notch/miR-223/FBXW7 pathway. Bioscience reports 2017; 37.

(3) Zhang H, Ge C, Lin C, et al. Combination of icotinib and wogonin induces apoptosis and autophagy to overcome acquired resistance in lung cancer harbouring EGFR T790M mutation[J]. International Journal of Clinical & Experimental Medicine, 2017, 10(5):7553-7562.

(4) Zhang H W, Wang E W, Li L X, et al. A regulatory loop involving miR-29c and Sp1 elevates the TGF-β1 mediated epithelial-to-mesenchymal transition in lung cancer[J]. Oncotarget, 2016, 7(52):85905.

(5) H.W. Zhang, Y. Yang, K. Zhang, L. Qiang, L. Yang, Y. Hu, X.T. Wang, Q.D. You*, Q.L. Guo*, Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCdelta phosphorylation. Eur J Pharmacol, 2008, 591:7-12.

(6) H. Zhang, Y. Zhang, S.S. Ng, F. Ren, Y. Wang, Y. Duan, L. Chen, Y. Zhai, Q. Guo*, Z. Chang*, Dishevelled-DEP domain interacting protein (DDIP) inhibits Wnt signaling by promoting TCF4 degradation and disrupting the TCF4/beta-catenin complex, Cell Signal, 2010, 22:1753-1760.

2. 既非第一作者又非通訊作者論文

(1) J. Yu, Q.L. Guo, Q.D. You, L. Zhao, H.Y. Gu, Y. Yang, H.W. Zhang, Z. Tan, X. Wang*, Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells. Carcinogenesis, 2007, 28:632-638.

(2) F. Wang, H. Zhang, X. Zhang, Y. Wang, F. Ren, Y. Zhai, and Z. Chang*, Varp interacts with Rab38 and functions as its potential effector. Biochem Biophys Res Commun, 2008, 372:162-167.

(3) L. Yang, H.W. Zhang, R. Hu, Y. Yang, Q. Qi, N. Lu, W. Liu, Y.Y. Chu, Q.D. You, Q.L. Guo*, Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells, Biochem Cell Biol, 2009, 87:933-942.

(4) Y. Wu, Y. Zhang, H. Zhang, X. Yang, Y. Wang, F. Ren, H. Liu, Y. Zhai, B. Jia, J. Yu, Z. Chang*, p15RS attenuates Wnt/{beta}-catenin signaling by disrupting {beta}-catenin.TCF4 Interaction, J Biol Chem, 2010, 285:34621-34631.

(5) L. Qiang, T. Wu, H.W. Zhang, N. Lu, R. Hu, Y.J. Wang, L. Zhao, F.H. Chen, X.T. Wang, Q.D. You, Q.L. Guo*. HIF-1alpha is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway, Cell Death Differ, 2012, 19:284-294.

（6）Wang, E., Wang, D., Li, B., Ma, H., Wang, C., & Guan, L., Zhang, H., Yi, L. (2017). Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the wnt/β-catenin pathway. Oncology Reports, 37(1), 379.